If you activate "Lone Wolf" targeting an appropriate monster, and later you Summon another monster, the effect of "Lone Wolf" is still applied.

If you target "Monk Fighter", etc. with "Lone Wolf", and "Monk Fighter" is later flipped face-down, the effect of "Lone Wolf" disappears and is not re-activated even if "Monk Fighter" is later flipped face-up again.

"Your opponent's monster effects" on "Lone Wolf" means "the effects of monsters that your opponent controls". So if your opponent uses "Monster Reborn" on your "Exiled Force", they still cannot Tribute "Exiled Force" to destroy your "Monk Fighter" targeted by "Lone Wolf".

If you Summon "Monk Fighter" and target it with "Lone Wolf", and your opponent controls "Big-Tusked Mammoth", you can still attack that same turn with "Monk Fighter".

If your "Master Monk" targeted with "Lone Wolf" attacks and destroys "D.D. Assailant", "D.D. Assailant" is removed from play but "Master Monk" is not.

If your opponent Summons "Dark Jeroid" and reduces your "Monk Fighter's" ATK by 800 points, then later you activate "Lone Wolf" targeting the "Monk Fighter", it does not restore the ATK of "Monk Fighter".

Your "Monk Fighter" targeted by "Lone Wolf" cannot be destroyed by the effect of "Tribe-Infecting Virus". Furthermore, if it is the only monster on your side of the field, your opponent cannot discard cards to activate "Tribe-Infecting Virus" to destroy Rock-Type monsters, because it will have no effect.

If you have "Monk Fighter" targeted by "Lone Wolf", the following are examples of monster effects that will NOT be negated because they are not applied to a monster: "Airknight Parshath" (damage is inflicted and a card is drawn), "Fiber Jar" ("Monk Fighter" is shuffled into the Deck), "Maju Garzett" (the ATK of "Maju Garzett" does not become 0), "Susa Soldier" (the damage to Life Points is still halved), "Dark Magician Girl" (her ATK is still increased by her effect), "Stone Statue of the Aztecs" (Battle Damage to your Life Points is doubled), "Amazoness Fighter" (opponent's Battle Damage to their Life Points is still zero), "Amazoness Swords Woman" (Battle Damage is still redirected), and "Reflect Bounder" (you still take Effect Damage to your Life Points).

"Archfiend of Gilfer" and "Dark Necrofear" in the Graveyard can activate their effects and target "Monk Fighter" targeted by "Lone Wolf". This is because they activate as Monster Cards, equip to the target monster, become treated as Equip Spell Cards, and THEN apply their effects (by which point they are now treated as Equip Spell Cards).

The effect of "Lone Wolf" will be negated by "Jinzo" even if targeting "Monk Fighter".

Winged Kuriboh LV10: If an opponent's monster cannot be destroyed by the effect of "Winged Kuriboh LV10", no damage is dealt for that monster's ATK. For example, if "Master Monk" targeted by "Lone Wolf" is on the field, it is unaffected by monster effects, so it will not be destroyed and its 1900 original ATK points will not be inflicted to its controller.